October 2002 Extramurally Speaking

CA Corresponding Author Fax: +81 195 78 3357 E-mail: [email protected] TW O {Met(0)}deacetyl-thymosin b 4 analogs containing Phe(4F) or Tyr(Me) at position 12 were synthesized by the manual solid-phase method, and their anti-inflammatory effect on carrageenin-induced edema in the mouse paw was studied. Fluorination of the para-position of Phe resulted in a marked antiinflammatory effect on carrageenin-induced edema in the mouse paw compared with that of our synthetic {Met(0)}deacetyl-thymosin b 4, but the other analog, {Met(0), Tyr(Me)}deacetyl-thymosin b 4, showed a marked reduction of the anti-inflammatory effect.